Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis.

Abstract excerpt

BACKGROUND: Embryonic ectoderm development (EED) protein is involved in multiple cellular protein complexes. EED mediates the repression of gene activity through histone deacetylation, and it may act as a specific regulator of integrin's function. This gene was identified as a candidate gene for the susceptibility to IBD by our previous cDNA microarray analysis. AIM: The present study aimed to validate the...

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