Article
Agents which modify colonial morphology of tumor cells also affect acid vesicle function and fibronectin deposition in the extracellular matrix.
Experimental cell research - 1 Nov 1990
Matthews N, Neale M L
Abstract excerpt
The tumor cell line U937A is motile, weakly plastic-adherent and forms large, loosely packed colonies in vitro and is invasive and metastatic in vivo. U937A/R, a mutant selected for resistance to killing by tumor necrosis factor (TNF), is less motile, more adherent and forms small, tightly packed colonies and is not invasive or metastatic. U937A and U937A/R also have differing cytoplasmic distributions of acid...
Topics
- Cell Movement
- Extracellular Matrix
- Fibronectins
- Fluorescent Antibody Technique
- Humans
- Organelles
- Phenotype
- Tumor Cells, Cultured