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Article

Structures of the lamin A/C R335W and E347K mutants: implications for dilated cardiolaminopathies.

Biochemical and biophysical research communications - 10 Feb 2012

Bollati Michela, Barbiroli Alberto, Favalli Valentina, Arbustini Eloisa, Charron Philippe, Bolognesi Martino

Abstract excerpt

Dilated cardiomyopathy (DCM) is a condition whereby the normal muscular function of the myocardium is altered by specific or multiple aetiologies. About 25-35% of DCM patients show familial forms of the disease, with most mutations affecting genes encoding cytoskeletal proteins. Most of the DCM-related mutations fall in the Lamin AC gene, in particular in the Coil2B domain of the encoded protein. In this context,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22266370
DOI: 10.1016/j.bbrc.2011.12.136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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