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Article

Additive effects of sonic hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cells.

Stem cells and development - 10 Aug 2012

James Aaron W, Pang Shen, Askarinam Asal, Corselli Mirko, Zara Janette N, Goyal Raghav, Chang Le, Pan Angel, Shen Jia, Yuan Wei, Stoker David, Zhang Xinli, Adams John S, Ting Kang, Soo Chia

Abstract excerpt

A theoretical inverse relationship exists between osteogenic (bone forming) and adipogenic (fat forming) mesenchymal stem cell (MSC) differentiation. This inverse relationship in theory partially underlies the clinical entity of osteoporosis, in which marrow MSCs have a preference for adipose dif...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22264144
DOI: 10.1089/scd.2011.0461
PMCID: PMC3411358

Genes

SHH
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22264144-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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