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Syndecan-1 Facilitates the Human Mesenchymal Stem Cell Osteo-Adipogenic Balance

29 May 2020

Abstract excerpt

Bone marrow-derived human mesenchymal stems cells (hMSCs) are precursors to adipocyte and osteoblast lineage cells. Dysregulation of the osteo-adipogenic balance has been implicated in pathological conditions involving bone loss. Heparan sulfate proteoglycans (HSPGs) such as cell membrane-bound syndecans (SDCs) and glypicans (GPCs) mediate hMSC lineage differentiation and with syndecan-1 (SDC-1) reported in both...

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PMID: 32485953
DOI: 10.3390/ijms21113884

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