Article
The removal from plasma of chylomicrons and remnants is reduced in heterozygous familial hypercholesterolemia subjects with identified LDL receptor mutations: study with artificial emulsions.
Atherosclerosis - 1 Mar 2012
Carneiro Marcia M, Miname Marcio H, Gagliardi Ana C, Pereira Carolina, Pereira Alexandre C, Krieger Jose E, Maranhão Raul C, Santos Raul D
Abstract excerpt
Chylomicron remnants bind to both their specific receptors (LRP) and to the LDL receptor (LDLR) in the liver. There is controversy whether disturbances of chylomicron metabolism occur in subjects with familial hypercholesterolemia (FH). The aim of this study was to evaluate whether there are defects on the removal from plasma of chylomicrons and their remnants in heterozygous FH patients with determined LDLR...
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