Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin.

doi:10.1002/jmv.23207

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Article

Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin.

Journal of medical virology - 1 Mar 2012

Hayashi Kazuhiko, Katano Yoshiaki, Kuzuya Teiji, Tachi Yoshihiko, Honda Takashi, Ishigami Masatoshi, Itoh Akihiro, Hirooka Yoshiki, Ishikawa Tetsuya, Nakano Isao, Urano Fumihiro, Yoshioka Kentaro, Toyoda Hidenori, Kumada Takashi, Goto Hidemi

Abstract excerpt

Hepatitis C virus (HCV) genotype 1a is rare in Japanese patients and the clinical characteristics of this genotype remain unclear. The interferon (IFN) sensitivity-determining region (ISDR) and single-nucleotide polymorphisms (SNPs) of interleukin-28B (IL28B) among patients with HCV genotype 1b are associated with IFN response, but associations among patients with genotype 1a are largely unknown. This study...

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PMID: 22246829
DOI: 10.1002/jmv.23207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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