Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCG2 null alleles define the Jr(a-) blood group phenotype.

Nature genetics - 15 Jan 2012

Zelinski Teresa, Coghlan Gail, Liu Xiao-Qing, Reid Marion E

Abstract excerpt

The high-incidence erythrocyte blood group antigen Jr(a) has been known in transfusion medicine for over 40 years. To identify the gene encoding Jr(a), we performed SNP analysis of genomic DNA from six Jr(a-) individuals. All individuals shared a homozygous region of 397,000 bp at chromosome 4q22.1 that contained the gene ABCG2, and DNA sequence analysis showed that ABCG2 null alleles define the Jr(a-) phenotype.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Base Sequence

Share to Blood Group Antigens

Share to Chromosomes, Human, Pair 4

Share to Homozygote

Share to Neoplasm Proteins

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 22246507
DOI: 10.1038/ng.1075

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCG2 null alleles define the Jr(a-) blood group phenotype.PMID 22246507Read ↗

The JR blood group system: identification of alleles that alter expression.Semantic proximity Read ↗

The JR blood group system (ISBT 032): molecular characterization of three new null alleles.Semantic proximity Read ↗

Defining the Jr(a-) phenotype in the Japanese population.Semantic proximity Read ↗

A new ABCG2 null allele with a 27-kb deletion including the promoter region causing the Jr(a-) phenotype.Semantic proximity Read ↗

A review of the JR blood group system.Semantic proximity Read ↗

Genotype Analysis of the JR Blood Group in an East Asian Population Using Tetra-Primer ARMS-PCR.Semantic proximity Read ↗

Molecular analysis of immunized Jr(a-) or Lan- patients and validation of a high-throughput genotyping assay to screen blood donors for Jr(a-) and Lan- phenotypes.Semantic proximity Read ↗

Gene identification of rare B(A) blood group.Semantic proximity Read ↗

Identification of human glycosyltransferase genes expressed in erythroid cells predicts potential carbohydrate blood group loci.Semantic proximity Read ↗

Using red blood cell genomics in transfusion medicine.Semantic proximity Read ↗

Novel JK*01 allele with c.299C>T p.(Thr100Ile) single nucleotide variant associated with loss of Jka expression in two African American donors.Semantic proximity Read ↗

Prevalence and molecular basis of null blood group phenotypes in the Korean population: Analysis using a public database.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.