Article
Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome.
Blood - 8 Mar 2012
Barbui Tiziano, Thiele Jürgen, Passamonti Francesco, Rumi Elisa, Boveri Emanuela, Randi Maria Luigia, Bertozzi Irene, Marino Filippo, Vannucchi Alessandro M, Pieri Lisa, Rotunno Giada, Gisslinger Heinz, Gisslinger Bettina, Müllauer Leonhard, Finazzi Guido, Carobbio Alessandra, Gianatti Andrea, Ruggeri Marco, Nichele Ilaria, D'Amore Emanuele, Rambaldi Alessandro, Tefferi Ayalew
Abstract excerpt
We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibrosis. Presenting clinical and laboratory characteristics, including JAK2V617F allele burden,...
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