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Article

Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma.

Blood - 23 Feb 2012

Klapper Wolfram, Kreuz Markus, Kohler Christian W, Burkhardt Birgit, Szczepanowski Monika, Salaverria Itziar, Hummel Michael, Loeffler Markus, Pellissery Shoji, Woessmann Wilhelm, Schwänen Carsten, Trümper Lorenz, Wessendorf Swen, Spang Rainer, Hasenclever Dirk, Siebert Reiner

Abstract excerpt

Diffuse large B-cell lymphoma is the most frequent type of B-cell lymphoma in adult patients but also occurs in children. Patients are currently assigned to therapy regimens based on arbitrarily chosen age limits only (eg, 18 or 60 years) and not biologically justified limits. A total of 364 diffuse large B-cell lymphomas and related mature aggressive B-cell lymphomas other than Burkitt lymphoma from all age...

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Topics

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Share to Comparative Genomic Hybridization
Share to Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Lymphoma, Large B-Cell, Diffuse

Share to Outcome Assessment, Health Care

Share to Polycomb Repressive Complex 2

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-bcl-6

Source

Identifiers

PMID: 22238326
DOI: 10.1182/blood-2011-10-388470

Genes

BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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