Interactome–transcriptome integration for predicting distant metastasis in breast cancer

Abstract excerpt

MOTIVATION: High-throughput gene expression profiling yields genomic signatures that allow the prediction of clinical conditions including patient outcome. However, these signatures have limitations, such as dependency on the training set, and worse, lack of generalization. RESULTS: We propose a novel algorithm called ITI (interactome-transcriptome integration), to extract a genomic signature predicting distant...

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