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Article

Core module biomarker identification with network exploration for breast cancer metastasis

18 Jan 2012

Abstract excerpt

BACKGROUND: In a complex disease, the expression of many genes can be significantly altered, leading to the appearance of a differentially expressed "disease module". Some of these genes directly correspond to the disease phenotype, (i.e. "driver" genes), while others represent closely-related first-degree neighbours in gene interaction space. The remaining genes consist of further removed "passenger" genes,...

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PMID: 22257533
DOI: 10.1186/1471-2105-13-12

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