Article
Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Oct 2012
Doyard M, Fatih N, Monnier A, Island M L, Aubry M, Leroyer P, Bouvet R, Chalès G, Mosser J, Loréal O, Guggenbuhl P
Abstract excerpt
UNLABELLED: In order to understand mechanisms involved in osteoporosis observed during iron overload diseases, we analyzed the impact of iron on a human osteoblast-like cell line. Iron exposure decreases osteoblast phenotype. HHIPL-2 is an iron-modulated gene which could contribute to these alterations. Our results suggest osteoblast impairment in iron-related osteoporosis. INTRODUCTION: Iron overload may cause...
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