Endothelial nitric oxide synthase haplotypes associated with aura in patients with migraine.

doi:10.1089/dna.2010.1152

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Article

Endothelial nitric oxide synthase haplotypes associated with aura in patients with migraine.

DNA and cell biology - 1 Jun 2011

Gonçalves Flavia M, Martins-Oliveira Alisson, Speciali Jose G, Luizon Marcelo R, Izidoro-Toledo Tatiane C, Silva Pamela S, Dach Fabiola, Tanus-Santos Jose E

Abstract excerpt

There is strong evidence implicating nitric oxide (NO) in the pathophysiology of migraine and aura. Therefore, genetic polymorphisms in the endothelial NO synthase (eNOS) gene have been studied as candidate markers for migraine susceptibility. We compared for the first time the distribution of eNOS haplotypes including the three clinically relevant eNOS polymorphisms (T(-786)C in the promoter, rs2070744;...

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PMID: 21332392
DOI: 10.1089/dna.2010.1152

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