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Article

PrP Antibodies Do Not Trigger Mouse Hippocampal Neuron Apoptosis

6 Jan 2012

Abstract excerpt

Intraperitoneal administration of ICSM18 and 35, monoclonal antibodies against prion protein (PrP), has been shown to significantly delay the onset of prion disease in mice, and humanized versions are candidate therapeutics for prion and Alzheimer's diseases. However, a previous report of severe and widespread apoptosis after intracerebral injection of anti-PrP monoclonal antibodies raised concerns about such...

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PMID: 22223800
DOI: 10.1126/science.1215579

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