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Article

Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice.

PloS one - 1 Jan 2011

Villarroya Joan, Dorado Beatriz, Vilà Maya R, Garcia-Arumí Elena, Domingo Pere, Giralt Marta, Hirano Michio, Villarroya Francesc

Abstract excerpt

Mammal adipose tissues require mitochondrial activity for proper development and differentiation. The components of the mitochondrial respiratory chain/oxidative phosphorylation system (OXPHOS) are encoded by both mitochondrial and nuclear genomes. The maintenance of mitochondrial DNA (mtDNA) is a key element for a functional mitochondrial oxidative activity in mammalian cells. To ascertain the role of mtDNA...

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PMID: 22216345
DOI: 10.1371/journal.pone.0029691
PMCID: PMC3246498

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