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Article

Collagen fibril diameter and alignment promote the quiescent keratocyte phenotype.

Journal of biomedical materials research. Part A - 1 Mar 2012

Muthusubramaniam Lalitha, Peng Lily, Zaitseva Tatiana, Paukshto Michael, Martin George R, Desai Tejal A

Abstract excerpt

In this study, we investigated how matrix nanotopography affects corneal fibroblast phenotype and matrix synthesis. To this end, corneal fibroblasts isolated from bovine corneas were grown on collagen nanofiber scaffolds of different diameters and alignment--30 nm aligned fibrils (30A), 300 nm or larger aligned fibrils (300A), and 30 nm nonaligned fibrils (30NA) in comparison with collagen coated flat glass...

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Identifiers

PMID: 22213336
DOI: 10.1002/jbm.a.33284
PMCID: PMC3266477

Genes

TKT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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