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Article

Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.

Journal of virology - 1 Mar 2012

Graci Jason D, Gnädig Nina F, Galarraga Jessica E, Castro Christian, Vignuzzi Marco, Cameron Craig E

Abstract excerpt

The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the...

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Source

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Identifiers

PMID: 22190724
DOI: 10.1128/JVI.05712-11
PMCID: PMC3302263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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