Article
Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.
Human mutation - 1 Mar 2012
Hong Mun-Gwan, Reynolds Chandra A, Feldman Adina L, Kallin Mikael, Lambert Jean-Charles, Amouyel Philippe, Ingelsson Erik, Pedersen Nancy L, Prince Jonathan A
Abstract excerpt
Genome-wide association studies (GWAS) that allow for allelic heterogeneity may facilitate the discovery of novel genes not detectable by models that require replication of a single variant site. One strategy to accomplish this is to focus on genes rather than markers as units of association, and so potentially capture a spectrum of causal alleles that differ across populations. Here, we conducted a GWAS of...
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