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Quantitative proteome analysis of multidrug resistance in human ovarian cancer cell line

15 Jan 2010

Abstract excerpt

In order to understand the molecular mechanisms of multidrug resistance (MDR) in ovarian cancer, we employed the proteomic approach of isobaric tags for relative and absolute quantification (iTRAQ), followed by LC-MS/MS, using the cisplatin-resistant COC1/DDP cell line and its parental COC1 cell line as a model. A total number of 28 proteins differentially expressed were identified, and then the differential...

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PMID: 20082317
DOI: 10.1002/jcb.22413

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