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Article

Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches.

The Journal of investigative dermatology - 1 Apr 2012

Cozzi Sarah-Jane, Ogbourne Steven M, James Cini, Rebel Heggert G, de Gruijl Frank R, Ferguson Blake, Gardner Joy, Lee Thuy T, Larcher Thibaut, Suhrbier Andreas

Abstract excerpt

Skin cancer is the most prevalent cancer worldwide and is primarily caused by chronic UV exposure. Here, we describe the topical field-directed treatment of SKH1/hr mice with UVB-damaged skin with ingenol mebutate, a new topical drug shown to be effective for the treatment of actinic keratosis (AK). Application of 0.05% ingenol mebutate gel to photo-damaged skin resulted in a ≈70% reduction in the number of skin...

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Identifiers

PMID: 22189786
DOI: 10.1038/jid.2011.418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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