Article
Relationship between type 2 diabetes mellitus and a novel polymorphism C698T in C5L2 in the Chinese Han population.
Endocrine - 1 Apr 2012
Zheng Ying-Ying, Xie Xiang, Ma Yi-Tong, Yang Yi-Ning, Fu Zhen-Yan, Li Xiao-Mei, Ma Xiang, Chen Bang-Dang, Liu Fen
Abstract excerpt
In a previous study, we reported a novel single nucleotide polymorphism (SNP) 698C>T (P233L) in the gene, C5L2. This gene has been demonstrated to encode a functional receptor of acylation-stimulating protein (ASP), a G-protein-coupled receptor (GPCR), that has been shown to influence insulin secretion in cultured pancreatic islet cells in vitro and is a stimulator of triglyceride synthesis and glucose transport...
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