Article
Metabolic and cardiovascular genes in polycystic ovary syndrome: a candidate-wide association study (CWAS).
Steroids - 10 Mar 2012
Jones Michelle R, Chua Angela K, Mengesha Emebet A, Taylor Kent D, Chen Yii-Der I, Li Xiaohui, Krauss Ronald M, Rotter Jerome I, Legro Richard S, Azziz Ricardo, Goodarzi Mark O
Abstract excerpt
The role of metabolic disturbance in polycystic ovary syndrome (PCOS) has been well established, with insulin resistance and the resulting compensatory hyperinsulinemia thought to promote hyperandrogenemia. Genome-wide association studies (GWAS) have established a large number of loci for metabolic conditions such as type 2 diabetes and obesity. A subset of these loci has been investigated for a role in PCOS;...
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