Article
Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy.
PloS one - 1 Jan 2011
Liao Haihui, Irvine Alan D, Macewen Caroline J, Weed Kathryn H, Porter Louise, Corden Laura D, Gibson A Bethany, Moore Jonathan E, Smith Frances J D, McLean W H Irwin, Moore C B Tara
Abstract excerpt
BACKGROUND: Meesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, the outermost covering of the eye. Typically, patients suffer from lifelong irritation of the eye and/or photophobia but rarely lose visual acuity; however, some individuals are severely...
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