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Article

XPC Lys939Gln polymorphism is associated with the decreased response to platinum based chemotherapy in advanced non-small-cell lung cancer.

Chinese medical journal - 1 Dec 2010

Zhu Xiao-Li, Sun Xin-Chen, Chen Bao-An, Sun Ning, Cheng Hong-Yan, Li Fan, Zhang Hong-Ming, Feng Ji-Feng, Qin Shu-Kui, Cheng Lu, Lu Zu-Hong

Abstract excerpt

BACKGROUND: Platinum-based chemotherapeutics are the most common regimens for advanced non-small-cell lung cancer (NSCLC) patients, and genetic factors are thought to represent important determinants of drug efficacy. We prospectively assessed the status of the XPC Ala499Val and Lys939Gln gene polymorphisms and investigated whether these SNPs can predict the response to cisplatin/carboplatin-based regimens in...

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Source

Identifiers

PMID: 22166526

Genes

XPC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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