Article
Canine intestinal mast cell tumor with c-kit exon 8 mutation responsive to imatinib therapy.
Veterinary journal (London, England : 1997) - 1 Jul 2012
Kobayashi Masato, Sugisaki Osamu, Ishii Noriko, Yamada Osamu, Ito Keita, Kuroki Shiori, Sasaki Yu, Ono Kenichiro, Washizu Tsukimi, Bonkobara Makoto
Abstract excerpt
A canine intestinal mast cell tumor with splenic metastasis was treated with imatinib. The intestinal and metastatic tumor masses markedly decreased following treatment although the clinical response was short lasting. A c-kit internal tandem duplication mutation, c.1250_1261dup, which causes an insertion of four amino acids in KIT, was identified in cDNA isolated from the tumor cells. The phosphorylation status...
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