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Article

Ethanol-tolerant gene identification in Clostridium thermocellum using pyro-resequencing for metabolic engineering.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Yang Shihui, Klingeman Dawn M, Brown Steven D

Abstract excerpt

Classic strain development that combines random mutagenesis and selection has a long history of success in generation of biocatalysts with industrially designed traits. However, the genetic loci contributing to the phenotypic strain changes are difficult to identify prior to genome sequencing technology advancement. In this chapter, we present the approach using Roche 454 next-generation pyro-resequencing to...

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PMID: 22144357
DOI: 10.1007/978-1-61779-483-4_9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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