Article
Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Stewart Mary K, Cummings Lisa A, Johnson Matthew L, Berezow Alex B, Cookson Brad T
Abstract excerpt
Sensing and adapting to the environment is one strategy by which bacteria attempt to maximize fitness in an unpredictable world; another is the stochastic generation of phenotypically distinct subgroups within a genetically clonal population. In culture, Salmonella Typhimurium populations are bistable for the expression of flagellin. We report that YdiV controls this expression pattern by preventing transcription...
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