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Article

Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition.

PloS one - 1 Jan 2011

Burdge Graham C, Hoile Samuel P, Uller Tobias, Thomas Nicola A, Gluckman Peter D, Hanson Mark A, Lillycrop Karen A

Abstract excerpt

Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between generations by a variety of mechanisms, including direct transmission of epigenetic states or by induction of epigenetic marks de novo in each generation. To distinguish between these possibilities we measured epigenetic marks over four generations in rats...

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Identifiers

PMID: 22140567
DOI: 10.1371/journal.pone.0028282
PMCID: PMC3227644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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