Article
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder.
Nature genetics - 4 Dec 2011
Elia Josephine, Glessner Joseph T, Wang Kai, Takahashi Nagahide, Shtir Corina J, Hadley Dexter, Sleiman Patrick M A, Zhang Haitao, Kim Cecilia E, Robison Reid, Lyon Gholson J, Flory James H, Bradfield Jonathan P, Imielinski Marcin, Hou Cuiping, Frackelton Edward C, Chiavacci Rosetta M, Sakurai Takeshi, Rabin Cara, Middleton Frank A, Thomas Kelly A, Garris Maria, Mentch Frank, Freitag Christine M, Steinhausen Hans-Christoph, Todorov Alexandre A, Reif Andreas, Rothenberger Aribert, Franke Barbara, Mick Eric O, Roeyers Herbert, Buitelaar Jan, Lesch Klaus-Peter, Banaschewski Tobias, Ebstein Richard P, Mulas Fernando, Oades Robert D, Sergeant Joseph, Sonuga-Barke Edmund, Renner Tobias J, Romanos Marcel, Romanos Jasmin, Warnke Andreas, Walitza Susanne, Meyer Jobst, Pálmason Haukur, Seitz Christiane, Loo Sandra K, Smalley Susan L, Biederman Joseph, Kent Lindsey, Asherson Philip, Anney Richard J L, Gaynor J William, Shaw Philip, Devoto Marcella, White Peter S, Grant Struan F A, Buxbaum Joseph D, Rapoport Judith L, Williams Nigel M, Nelson Stanley F, Faraone Stephen V, Hakonarson Hakon
Abstract excerpt
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of...
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