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Article

Alterations in promoter methylation status of tumor suppressor HIC1, SFRP2, and DAPK1 genes in prostate carcinomas.

DNA and cell biology - 1 May 2012

Kilinc Devran, Ozdemir Oztürk, Ozdemir Semra, Korgali Esat, Koksal Binnur, Uslu Atilla, Gultekin Yener E

Abstract excerpt

Hypermethylated genomic DNA is a common feature in tumoral tissues, although the prevalence of this modification remains poorly understood. We aimed to determine the frequency of five tumor suppressor (TS) genes in prostate cancer and the correlation between promoter hypermethylation of these genes and low and high grade of prostate carcinomas. A total of 30 prostate tumor specimens were investigated for promoter...

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Identifiers

PMID: 22136354
DOI: 10.1089/dna.2011.1431

Genes

DAPK1
HIC1
SFRP2
MGMT

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