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Article

Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells.

PloS one - 1 Jan 2011

Wang Xuewei, Nath Aritro, Yang Xuerui, Portis Amanda, Walton S Patrick, Chan Christina

Abstract excerpt

The regulation of complex cellular activities in palmitate treated HepG2 cells, and the ensuing cytotoxic phenotype, involves cooperative interactions between genes. While previous approaches have largely focused on identifying individual target genes, elucidating interacting genes has thus far remained elusive. We applied the concept of information synergy to reconstruct a "gene-cooperativity" network for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22132232
DOI: 10.1371/journal.pone.0028138
PMCID: PMC3223234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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