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Article

Deficient Spindle Assembly Checkpoint in Multiple Myeloma

23 Nov 2011

Abstract excerpt

Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and chromosomal gains and losses. In fact, a singular characteristic differentiating MM from other hematological malignancies is the presence of a high degree of...

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PMID: 22132115
DOI: 10.1371/journal.pone.0027583

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