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Article

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study.

The Lancet. Oncology - 1 May 2005

Moroni Mauro, Veronese Silvio, Benvenuti Silvia, Marrapese Giovanna, Sartore-Bianchi Andrea, Di Nicolantonio Federica, Gambacorta Marcello, Siena Salvatore, Bardelli Alberto

Abstract excerpt

BACKGROUND: The antiepidermal growth factor receptor (antiEGFR) monoclonal antibodies cetuximab and panitumumab have good clinical activity in about 10% of patients with metastatic colorectal cancer that is resistant to chemotherapy. The molecular mechanisms underlying clinical response or resistance to these agents are unknown. METHODS: Tumours from 31 patients with metastatic colorectal cancer who had either an...

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Source

Identifiers

PMID: 15863375
DOI: 10.1016/S1470-2045(05)70102-9

Genes

EGFR
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study.PMID 15863375Read ↗

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