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Article

Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration.

Science signaling - 29 Nov 2011

Minetti Giulia C, Feige Jerome N, Rosenstiel Antonia, Bombard Florian, Meier Viktor, Werner Annick, Bassilana Frederic, Sailer Andreas W, Kahle Peter, Lambert Christian, Glass David J, Fornaro Mara

Abstract excerpt

Skeletal muscle atrophy results in loss of strength and an increased risk of mortality. We found that lysophosphatidic acid, which activates a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor, stimulated skeletal muscle hypertrophy through activation of Gα(i2). Expression of a constitutively active mutant of Gα(i2) stimulated myotube growth and differentiation, effects that required...

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Share to GTP-Binding Protein alpha Subunits, G12-G13
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22126963
DOI: 10.1126/scisignal.2002038

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