Two divergent routes of evolution gave rise to the DRw13 haplotypes.

Article

Two divergent routes of evolution gave rise to the DRw13 haplotypes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1990

Lee K W, Johnson A H, Hurley C K

Abstract excerpt

The HLA class II genes and haplotypes have evolved over a long period of evolutionary time by mechanisms such as gene conversion, reciprocal recombination and point mutation. The extent of the diversity generated is most clearly evident in an analysis of the HLA class II alleles present within DR...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Biological Evolution
Black People
Gene Conversion
HLA-DQ Antigens
HLA-DR Antigens
HLA-DR Serological Subtypes
Haplotypes
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Recombination, Genetic

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