Article
Two divergent routes of evolution gave rise to the DRw13 haplotypes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1990
Lee K W, Johnson A H, Hurley C K
Abstract excerpt
The HLA class II genes and haplotypes have evolved over a long period of evolutionary time by mechanisms such as gene conversion, reciprocal recombination and point mutation. The extent of the diversity generated is most clearly evident in an analysis of the HLA class II alleles present within DRw13 haplotypes. This study uses cDNA sequencing to examine the first domains of DRB1, DRB3, DQA1, and DQB1 alleles from...
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