Article
Notch1 receptor as a marker of lymph node metastases in papillary thyroid cancer.
Cancer science - 1 Feb 2012
Park Hyung Seok, Jung Chan-Kwon, Lee Sung Hak, Chae Byung Joo, Lim Dong Jun, Park Woo Chan, Song Byung Joo, Kim Jeong Soo, Jung Sang Seol, Bae Ja-Seong
Abstract excerpt
Notch functions as an oncogene or tumor suppressor according to the type of malignancy, and the BRAF(V600E) mutation is commonly observed in thyroid cancer. However, the role of Notch and BRAF(V600E) in papillary thyroid cancer (PTC) is unclear. This study sought to elucidate the clinicopathological characteristics in patients with PTC regarding the expression of Notch1/Notch3 receptors and BRAF(V600E) mutation....
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