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Article

Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones.

The Journal of biological chemistry - 6 Jan 2012

Ma Lijie, Liu Yan, El-Achkar Tarek M, Wu Xue-Ru

Abstract excerpt

Correct folding of a nascent polypeptide in the lumen of the endoplasmic reticulum (ER) into a three-dimensional conformation is a crucial step in the stability, intracellular trafficking, and targeting to the final destination of a protein. By transiently and stably expressing human-relevant mutants of Tamm-Horsfall protein in polarized Madin-Darby canine kidney cells, we show here that a cysteine-altering...

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Identifiers

PMID: 22117067
DOI: 10.1074/jbc.M111.283036
PMCID: PMC3256885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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