Article
Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese.
Human molecular genetics - 1 Mar 2012
Guo Youling, Baum Larry W, Sham Pak Chung, Wong Virginia, Ng Ping Wing, Lui Colin Hiu Tung, Sin Ngai Chuen, Tsoi Tak Hong, Tang Clara S M, Kwan Johnny S H, Yip Benjamin H K, Xiao Su-Mei, Thomas G Neil, Lau Yu Lung, Yang Wanling, Cherny Stacey S, Kwan Patrick
Abstract excerpt
In the majority of patients, epilepsy is a complex disorder with multiple susceptibility genes interacting with environmental factors. However, we understand little about its genetic risks. Here, we report the first genome-wide association study (GWAS) to identify common susceptibility variants of epilepsy in Chinese. This two-stage GWAS included a total of 1087 patients and 3444 matched controls. In the combined...
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