Article
Genetic Variation in PADI6-PADI4 on 1p36.13 Is Associated with Common Forms of Human Generalized Epilepsy.
Genes - 18 Sept 2021
Buono Russell J, Bradfield Jonathan P, Wei Zhi, Sperling Michael R, Dlugos Dennis J, Privitera Michael D, French Jacqueline A, Lo Warren, Cossette Patrick, Schachter Steven C, Basehore Heather, Lohoff Falk W, Grant Struan F A, Ferraro Thomas N, Hakonarson Hakon
Abstract excerpt
We performed a genome-wide association study (GWAS) to identify genetic variation associated with common forms of idiopathic generalized epilepsy (GE) and focal epilepsy (FE). Using a cohort of 2220 patients and 14,448 controls, we searched for single nucleotide polymorphisms (SNPs) associated with GE, FE and both forms combined. We did not find any SNPs that reached genome-wide statistical significance (p ≤ 5 ×...
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