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Article

The APL paradigm and the "co-clinical trial" project.

Cancer discovery - 1 Jul 2011

Nardella Caterina, Lunardi Andrea, Patnaik Akash, Cantley Lewis C, Pandolfi Pier Paolo

Abstract excerpt

Tremendous advances in technologies have allowed the attainment of powerful insights into the molecular and genetic determinants that drive human cancers. However, this acquired knowledge has been translated into effective therapeutics very slowly, in part due to difficulty in predicting which drug or drug combination is likely to be effective in the complex mutational background of human cancers. To address this...

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Identifiers

PMID: 22116793
DOI: 10.1158/2159-8290.CD-11-0061
PMCID: PMC3222327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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