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Article

Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

24 Nov 2011

Abstract excerpt

BACKGROUND: Hemophilia A is a bleeding disorder caused by deficiency in coagulation factor VIII. Recombinant factor VIII (rFVIII) is an alternative to plasma-derived FVIII for the treatment of hemophilia A. However, commercial manufacturing of rFVIII products is inefficient and costly and is associated to high prices and product shortage, even in economically privileged countries. This situation may be solved by...

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PMID: 22115125
DOI: 10.1186/1472-6750-11-114

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