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Article

CHEK2 contribution to hereditary breast cancer in non-BRCA families.

Breast cancer research : BCR - 1 Jan 2011

Desrichard Alexis, Bidet Yannick, Uhrhammer Nancy, Bignon Yves-Jean

Abstract excerpt

BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are responsible for only a part of hereditary breast cancer (HBC). The origins of "non-BRCA" HBC in families may be attributed in part to rare mutations in genes conferring moderate risk, such as CHEK2, which encodes for an upstream regulator of BRCA1. Previous studies have demonstrated an association between CHEK2 founder mutations and non-BRCA HBC. However,...

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Identifiers

PMID: 22114986
DOI: 10.1186/bcr3062
PMCID: PMC3326561

Genes

CHEK2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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