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Article

Allelic combinations of immune-response genes associated with glatiramer acetate treatment response in Russian multiple sclerosis patients.

Pharmacogenomics - 1 Jan 2012

Tsareva Ekaterina Y, Kulakova Olga G, Boyko Alexey N, Shchur Sergey G, Lvovs Dmitrijs, Favorov Alexander V, Gusev Evgeny I, Vandenbroeck Koen, Favorova Olga O

Abstract excerpt

BACKGROUND: Glatiramer acetate (GA) is widely used as a first-line disease-modifying treatment for multiple sclerosis (MS). However, a significant proportion of MS patient appears to experience modest benefit from GA-treatment. Genetic variants affecting the clinical response to GA are believed to be relevant as biomarkers of GA-treatment efficiency. PATIENTS & METHODS: Nine polymorphisms in candidate genes were...

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Share to Biomarkers, Pharmacological
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DRB1 Chains

Share to Multifactorial Inheritance

Share to Multiple Sclerosis

Share to Receptor, Interferon alpha-beta

Share to Receptors, CCR5

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 22111603
DOI: 10.2217/pgs.11.136

Genes

CCR5
TGFB1
IFNAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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