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Article

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs

21 Nov 2011

Abstract excerpt

Spliceosomes remove introns from primary gene transcripts. They assemble de novo on each intron through a series of steps that involve the incorporation of five snRNP particles and multiple non-snRNP proteins. In mammals, all the intermediate complexes have been characterized on one transcript (MINX), with the exception of the very first, complex E. We have purified this complex by two independent procedures...

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PMID: 22110043
DOI: 10.1093/nar/gkr1056

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