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Article

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Chemical biology & drug design - 1 Feb 2012

Zhao Xue Zhi, Maddali Kasthuraiah, Metifiot Mathieu, Smith Steven J, Vu B Christie, Marchand Christophe, Hughes Stephen H, Pommier Yves, Burke Terrence R

Abstract excerpt

HIV-1 integrase (IN) is a validated therapeutic target for the treatment of AIDS. However, the emergence of resistance to raltegravir, the sole marketed FDA-approved IN inhibitor, emphasizes the need to develop second-generation inhibitors that retain efficacy against clinically relevant IN mutants. We report herein bicyclic hydroxy-1H-pyrrolopyridine-triones as a new family of HIV-1 integrase inhibitors that...

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Identifiers

PMID: 22107736
DOI: 10.1111/j.1747-0285.2011.01270.x
PMCID: PMC6385889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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