Article
CCR5 promoter haplotype transcription complex characterization.
Journal of health care for the poor and underserved - 1 Jan 2011
Jiang Daifeng, Mummidi Srinivas, Ahuja Sunil K, Jarrett Harry W
Abstract excerpt
CC chemokine receptor 5 (CCR5) is a major coreceptor for cell entry of human immunodeficiency virus (HIV); its expression is highly associated with virus replication and susceptibility. Single nucleotide polymorphisms (SNPs) in the CCR5 promoter play a critical role in CCR5 transcriptional regulation. HHA and HHE represent two contrasting haplotypes of CCR5 with only two base pair differences in the promoter....
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