Article
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice.
PloS one - 1 Jan 2011
Geurts Nathalie, Martens Erik, Verhenne Sebastien, Lays Natacha, Thijs Greet, Magez Stefan, Cauwe Bénédicte, Li Sandra, Heremans Hubertine, Opdenakker Ghislain, Van den Steen Philippe E
Abstract excerpt
The use of genetically modified mice, i.e. transgenic as well as gene knockout (KO) and knock-in mice, has become an established tool to study gene function in many animal models for human diseases. However, a gene functions in a particular genomic context. This implies the importance of a well-defined homogenous genetic background for the analysis and interpretation of phenotypes associated with genetic...
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