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Article

A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2012

Shanmugam Rajasubramaniam, Gade Padmaja, Wilson-Weekes Annique, Sayar Hamid, Suvannasankha Attaya, Goswami Chirayu, Li Lang, Gupta Sushil, Cardoso Angelo A, Baghdadi Tareq Al, Sargent Katie J, Cripe Larry D, Kalvakolanu Dhananjaya V, Boswell H Scott

Abstract excerpt

PURPOSE: Death-associated protein kinase 1 (DAPK1), a tumor suppressor, is a rate-limiting effector in an endoplasmic reticulum (ER) stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in several tumors. A mechanistic basis for epigenetic/transcriptional repression of DAPK1 was investigated in certain forms of acute myeloid leukemia (AML) with poor prognosis, which lacked ER...

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Share to Apoptosis Regulatory Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22096027
DOI: 10.1158/1078-0432.CCR-10-3022
PMCID: PMC3918433

Genes

DAPK1
HDAC2
HDAC6

Provenance

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