Article
AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome.
BMC genomics - 17 Nov 2011
Mei Lingling, Ding Xiaofan, Tsang Shui-Ying, Pun Frank W, Ng Siu-Kin, Yang Jianfeng, Zhao Cunyou, Li Dezhi, Wan Weiqing, Yu Chi-Hung, Tan Tze-Ching, Poon Wai-Sang, Leung Gilberto Ka-Kit, Ng Ho-Keung, Zhang Liwei, Xue Hong
Abstract excerpt
BACKGROUND: To complement next-generation sequencing technologies, there is a pressing need for efficient pre-sequencing capture methods with reduced costs and DNA requirement. The Alu family of short interspersed nucleotide elements is the most abundant type of transposable elements in the human genome and a recognized source of genome instability. With over one million Alu elements distributed throughout the...
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